STRC Research

index

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STRC Index

Entry catalog for the STRC research vault. Read this first or jump to Dashboard for live state. Split from ~/Brain/ on 2026-04-24. Last updated: 2026-04-24.

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Active Hypotheses (by tier)

TABLE WITHOUT ID
  hypothesis_num AS "#",
  file.link AS "Hub",
  tier AS "Tier",
  mech AS "Mech",
  deliv AS "Deliv",
  misha_fit AS "Misha",
  next_step AS "Next"
FROM "hypotheses"
WHERE type = "hypothesis-hub"
SORT tier ASC, hypothesis_num ASC
#HubTierMechDelivMishaNext
1hubA344Phase 5e mutant re-dock running (v3b YELLOW pocket-stability gate); then Phase 3c v4 fragment-grow on 3-amino-benzofuran-2-COOH scaffold
5hubA342SPR/BLI E1659A affinity penalty
9hubA433Phase 2c WH2 bundling + 4b AF3
2hubB215Find OHC ligand + FEM strain-share
4hubB322Academic/interim if AAV fails
6hubB222Retrieve OHC RBM24 titration lit
26hubB254Phase 1d AF3 A1078C/S1080C/S1579C
7hubC321Wet-lab ribosome-profiling STRCP1
8hubC232Phase 3a morpholino + 3b gapmer
10hubC222Wet-lab only if #3 fails
11hubC222Alt scaffold deferred
12hubC222Speculative; no near-term path
13hubC213Technology-watch only
14hubC213No delivery route
27hubC224Email Holt lab ribosome-profiling
15hubD222Chimera dead; upregulation weak
16hubD321Wrong patient (paternal 98kb Δ)
3hubS554Order gBlock, clone pAAV, coIP

Papers (most recent)

TABLE WITHOUT ID
  file.link AS "Paper",
  paper_year AS "Year",
  relevance_type AS "Type",
  relevance_score AS "Score",
  status AS "Status"
FROM "papers"
WHERE type = "paper"
SORT paper_year DESC, file.mtime DESC
LIMIT 20

(no results)

Core concept notes

LIST file.link
FROM "notes"
WHERE contains(tags, "strc") AND type = "note"
SORT file.name ASC

Literature topics

LIST file.link
FROM "literature"
WHERE type = "literature-topic"
SORT file.name ASC

(no results)

External stubs (Brain-vault bridges)

LIST file.link
FROM "external"
WHERE type = "external-stub"
SORT file.name ASC

Connections

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