Stub hub. Details in STRC mRNA-LNP Strategy B Full-Length. State lives in frontmatter above.
next step
Academic/interim if AAV fails
Recent activity
const p = dv.page(dv.current().file.folder + "/log.md")
if (p && p.file.lists.length) dv.list(p.file.lists.slice(0, 5).map(l => l.text))
else dv.paragraph("_(no log entries)_")- h04 log
- strc
- h04
- #6 mRNA Therapy post-audit partial fix: A held. STRC_HL_D + RBM24_HL_D reframed from ⚠ UNSOURCED to lit-anchored OOM estimates (Zhang 2012 Nature PMID 22246323 for stereocilia <10 %/day; Mauriac 2024 PNAS PMID 39320919 for GPSM2 t½ 9–10 d; Schwanhäusser 2011 Nature PMID 21593866 for proteome median 46h). Hill K_M/n/max_boost stay CIRCULAR FIT (no OHC splicing dose-response lit exists). #4 Strategy B inherits. → STRC h06 Parameter Provenance Audit 2026-04-23
- #4 Strategy B: S → B. Misha-fit 5→2. Stack PKPD: adds 0.12-0.92% cochlea-mean at realistic AAV. → STRC AAV-LNP Stack PKPD
Connections
[part-of]STRC Hypothesis Ranking[see-also]STRC mRNA-LNP Strategy B Full-Length