Dual Vector AAV Strategy
A gene therapy delivery approach where the therapeutic gene is split across two AAV vectors that recombine inside target cells. Required for large genes that exceed single AAV packaging capacity (~4.7 kb).
Relevance to Misha: STRC gene (~6 kb coding) exceeds single AAV capacity. Iranfar et al. (2026) demonstrated dual-vector AAV delivery of STRC with functional restoration in mouse models.
Connections
[applies]Misha — STRC gene therapy delivery mechanism[applies]STRC Gene Therapy Landscape 2026[source]Iranfar 2026 — Dual AAV STRC — key paper demonstrating this approach[source]Duan_2018_micro_dystrophin_AAV — foundational dual-vector work[see-also]Omichi_2020_AAV_hair_cell_transduction — AAV serotype optimization for OHC[part-of]STRC Gene Therapy Landscape 2026