Stub hub. Details in STRC mRNA Therapy Hypothesis. State lives in frontmatter above.
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Retrieve OHC RBM24 titration lit
Recent activity
const p = dv.page(dv.current().file.folder + "/log.md")
if (p && p.file.lists.length) dv.list(p.file.lists.slice(0, 5).map(l => l.text))
else dv.paragraph("_(no log entries)_")- h06 log
- strc
- h06
- #6 mRNA Therapy: A → B. Mech 3→2. Hill-sensitivity sweep 125-pt grid (HILL_K × HILL_N × MAX_BOOST) shows per-OHC ROBUST (60% grid reaches tx_trough ≥ 2×) but cochlea-mean therapeutic ARCHITECTURALLY IMPOSSIBLE at LNP eff ≤ 20% for ANY Hill params — identity
cochlea_mean ≤ 1 + eff·(max_boost-1)caps ceiling at 1.80× even at MAX_BOOST=5, OHC-targeted 20%. Reframes stack A+B as “B + marginal A” not synergistic. → STRC h06 Hill Sensitivity Sweep 2026-04-23 - #6 mRNA Therapy post-audit partial fix: A held. STRC_HL_D + RBM24_HL_D reframed from ⚠ UNSOURCED to lit-anchored OOM estimates (Zhang 2012 Nature PMID 22246323 for stereocilia <10 %/day; Mauriac 2024 PNAS PMID 39320919 for GPSM2 t½ 9–10 d; Schwanhäusser 2011 Nature PMID 21593866 for proteome median 46h). Hill K_M/n/max_boost stay CIRCULAR FIT (no OHC splicing dose-response lit exists). #4 Strategy B inherits. → STRC h06 Parameter Provenance Audit 2026-04-23
Connections
[part-of]STRC Hypothesis Ranking[see-also]STRC mRNA Therapy Hypothesis