Stub hub. Details in STRC mRNA Therapy Hypothesis. State lives in frontmatter above.
next step
No fast compute-to-S path; needs primary OHC RBM24 titration or Sun 2026 quantification before another model can change tier.
Recent activity
const p = dv.page(dv.current().file.folder + "/log.md")
if (p && p.file.lists.length) dv.list(p.file.lists.slice(0, 5).map(l => l.text))
else dv.paragraph("_(no log entries)_")- h06 log
- strc
- h06
- B-tier promotion triage: Hill sensitivity rerun confirms per-OHC therapeutic behavior is robust across 60% of the scenario grid, but 0% clears cochlea-mean rescue at 5% or 20% OHC delivery; 20% delivery ceiling remains 1.8x. Tier B held; next_step reframed to no further compute-to-S without primary OHC RBM24 titration / quantitative Sun 2026 STRC splicing data. → STRC B-Tier Promotion Triage 2026-04-27
- #6 mRNA Therapy lit-audit closure: Hill K_M/n/max_boost CONFIRMED NOT MEASURED (no primary paper; Sun 2026 PNAS PMID 41973913 qualitative only; scripts updated with WARNING). STRC_HL_D + RBM24_HL_D anchors VERIFIED via PMC full text (Zhang 2012 PMC3267870: cochlear ~2%/day; Hartig 2024 PMC11459194: GPSM2 t½ 9.05–10.14 d; Schwanhäusser 2011 BioNumbers 106377: median 46 h). AUTHOR CORRECTION: “Mauriac & Barr-Gillespie 2024” → Hartig et al. 2024 (PI Tarchini). LNP OHC 20% aspirational confirmed (no primary paper). Gao 2020 phantom confirmed removed. lit_audit → fixed. → STRC h06 Parameter Provenance Audit 2026-04-25
Connections
[part-of]STRC Hypothesis Ranking[see-also]STRC mRNA Therapy Hypothesis