TLand

Organ-specific machine-learning architecture for prioritizing regulatory variants.

Key Info

• URL: https://github.com/Weng-Lab/TLand BROKEN — repo does not exist
• Category: Regulatory
• API: Unknown (repo removed)
• Free: Free
• ACMG Relevance: PP3
• Link Status: BROKEN 2026-04-09 — GitHub repo not found. Weng Lab repos exist but TLand not among them. May be paper-only or pre-publication.

Why It Matters

Overcomes typical model bias toward high-data cell lines by prioritizing non-coding variants for GWAS traits at the precise organ level.

How to Use

GitHub repo no longer available. Check the original publication for alternative access or contact Weng Lab. Consider RegulomeDB or Enformer as active alternatives for regulatory variant analysis.

STRC Research Usage

Not directly applicable to E1659A via API. Requires local installation or web interface. See documentation for manual usage.

Next Steps

• Test with STRC E1659A variant
• Verify API access
• Document specific results

Connections

• STRC Variant c.4976A>C — Misha [see-also]
• STRC Gene [about]