Hereditary Hearing Loss Homepage
Comprehensive resource for genes involved in hereditary hearing loss. Maps loci (DFNA, DFNB, DFNX) to genes and maintains current research references.
What It Does
- Complete list of deafness genes and loci
- DFNB (recessive), DFNA (dominant), DFNX (X-linked) classification
- Gene-locus-phenotype mapping
- Literature references per gene
- Research group contact information
How to Use
Web
- Go to https://hereditaryhearingloss.org
- Navigate: Autosomal Recessive → DFNB16 → STRC
- View gene information, references, clinical details
Verified Status
VERIFIED — STRC listed under DFNB16. Page includes gene description, hearing phenotype, and key references.
STRC Research Usage
- STRC Hearing Loss — reference for DFNB16 classification
- STRC Gene — gene-locus mapping
Results (April 2026)
- Research groups DONE: 4 key labs identified — Holt (Harvard), Shu (Fudan), Safieddine (Pasteur), Iranfar lab. Holt and Shu contacted directly.
- Related loci: OTOF (DFNB9) is proof-of-concept for inner ear gene therapy, TMC1 (DFNB7/11) in pre-clinical
- Next: systematic mapping of DFNB mouse models with hearing restoration data
Connections
- OMIM [see-also] — gene-disease reference
- Deafness Variation Database [see-also] — variant classifications
- STRC Hearing Loss [used-in]
- STRC Gene [used-in]