Deafness Variation Database (DVD)
Curated database of variants in genes associated with hearing loss. Expert-reviewed classifications specific to deafness genetics.
What It Does
- Variant classifications specific to hearing loss genes
- Expert panel curation (ClinGen Hearing Loss VCEP)
- Gene-specific ACMG criteria adaptations
- Phenotype-genotype correlations for deafness
How to Use
Web
- Go to https://deafnessvariationdatabase.org
- Search: “STRC” or specific variant
- Review expert-curated classifications
Verified Status
VERIFIED — STRC variants catalogued with hearing loss associations and classifications. Web-only access (no public API). Need to manually search for E1659A specifically.
Results (April 2026)
- STRC variants found in DVD with hearing loss associations and classifications (web-only access)
- E1659A: needs manual search on web interface (no API)
- Next: manually search DVD for E1659A, extract STRC-specific ACMG adaptations if any exist, phenotype-genotype correlations
Connections
- ClinVar [see-also] — DVD submits to ClinVar
- ClinGen [see-also] — Hearing Loss VCEP
- OMIM [see-also] — disease reference
- Hereditary Hearing Loss Homepage [see-also]