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Tag: selectivity
10 items with this tag.
Apr 26, 2026
Phase 7I — APBS off-target rescore (CONHOH lead vs CONHOMe Tier-1)
h01
apbs
off-target
selectivity
head-swap
CONHOH
CONHOMe
Apr 26, 2026
Phase 8h-lite #3 · Off-target selectivity charge proxy (inconclusive light)
strc
h01
off-target
selectivity
electrostatics
Apr 26, 2026
STRC h01 Phase 8g-v2 APBS Off-Target Rescore 2026-04-26
strc
h01
selectivity
apbs
off-target
phase-proof
Apr 26, 2026
STRC h01 Phase 8g-v3-lite + 8h-lite 9 Pocket Max Phi + Dose Sweep 2026-04-26
strc
h01
selectivity
apbs
pbpk
dose-escalation
phase-proof
Apr 26, 2026
Hydroxamic Acid Divalent Cation Liability
strc
h01
chemotype
off-target
selectivity
Apr 25, 2026
STRC h01 Phase 8g v5.2 Off-Target Panel 2026-04-25
strc
h01
phase-proof
phase8
off-target
selectivity
vina-limitation
pharmacochaperone
Apr 24, 2026
STRC h01 Phase 6c COX Selectivity Panel 2026-04-24
strc
h01
pharmacochaperone
selectivity
off-target
cox
tox-screen
proof
phase-proof
Apr 24, 2026
STRC h01 Phase 6c Full 6-Target Panel 2026-04-24
strc
h01
pharmacochaperone
selectivity
off-target
cox
tmem16a
trpm4
kcnq4
cx50
proof
phase-proof
Apr 24, 2026
STRC h01 Phase 6c hERG Extension 2026-04-24
strc
h01
phase-proof
phase6c
hERG
cardiac-safety
selectivity
off-target
Apr 21, 2026
STRC Pharmacochaperone Phase 4e Off-Target Selectivity
strc
e1659a
pharmacochaperone
phase4
selectivity
off-target
virtual-screening
decision-gate
proxy
h01
phase-proof