STRC Protein Visualization

What

Stereocilin (STRC) protein data for 3D visualization and computational analysis.

UniProt Record

• UniProt ID: Q7RTU9
• Protein: Stereocilin (STRC)
• Length: 1,809 amino acids
• Organism: Homo sapiens
• FASTA endpoint: https://rest.uniprot.org/uniprotkb/Q7RTU9.fasta
• Disease associations: DFNB16 (autosomal recessive hearing loss), Deafness-Infertility Syndrome
• Paralog: OTOA (otoancorin) — shares structural similarity

Context (2026-03-21)

Egor is experimenting with a protein visualization app (screenshot showed cytochrome C at 105 aa as test protein). Goal: replace test protein with STRC (Q7RTU9, 1809 aa) to visualize stereocilin structure.

Connects directly to computational analysis work at strc.egor.lol — making STRC structure accessible to researchers and families visually.

Why 1809 aa Matters for Gene Therapy

STRC is a very large protein — 1809 residues. This matters for:

• Gene therapy vector sizing: STRC cDNA ~5.4 kb, too large for single AAV at full length
• Mini-STRC hypothesis: N-terminus is dispensable, truncated version fits single vector
• Visualization reveals which domains are likely dispensable vs essential

Related Computational Work

• AlphaFold3 structure predictions (20 jobs completed as of 2026-03-20)
• SignalP, NetGPI, DeepLoc, NetNGlyc, IUPred3, ESMFold, conservation analysis — all completed
• Full suite validated and presented at strc.egor.lol

Connections

• [about] Misha
• [see-also] STRC Gene Therapy Landscape 2026
• [see-also] STRC Research Portal
• [see-also] MISHA Foundation
• [see-also] STRC Mini-STRC Single-Vector Hypothesis
• [see-also] Jeffrey Holt — his lab studies STRC structure for minigene approach
• [see-also] STRC AlphaFold3 Computational Experiments