h04 log

2026-04-23

#6 mRNA Therapy post-audit partial fix: A held. STRC_HL_D + RBM24_HL_D reframed from ⚠ UNSOURCED to lit-anchored OOM estimates (Zhang 2012 Nature PMID 22246323 for stereocilia <10 %/day; Mauriac 2024 PNAS PMID 39320919 for GPSM2 t½ 9–10 d; Schwanhäusser 2011 Nature PMID 21593866 for proteome median 46h). Hill K_M/n/max_boost stay CIRCULAR FIT (no OHC splicing dose-response lit exists). #4 Strategy B inherits. → STRC h06 Parameter Provenance Audit 2026-04-23
#4 Strategy B: S → B. Misha-fit 5→2. Stack PKPD: adds 0.12-0.92% cochlea-mean at realistic AAV. → STRC AAV-LNP Stack PKPD

Note created. Initial assignment 24 hypotheses. S: {#1 Pharmacochaperone, #2 Piezo, #3 Mini-STRC, #4 Strategy B}. Killed: {OTOA chimera, ZP prion, protein replacement}. Paused: {Sonogenetics, Recombinases}.