mCSM

Predicts stability and binding affinity changes utilizing graph-based spatial signatures.

What it does

Excellent for mapping how missense variants disrupt the highly specific topologies of protein-protein interfaces.

How to use

See https://biosig.lab.uq.edu.au/mcsm/ for documentation and access.

STRC usage

PARTIAL — API not responding. Web interface at biosig.lab.uq.edu.au/mcsm/ requires manual PDB upload. Graph-based stability prediction complements our Coulomb analysis.

Connections

• STRC Variant c.4976A>C — Misha [see-also]
• STRC Gene [about]
• [part-of] Tools index