PrimateAI-3D

Evaluates missense variants by integrating 3D protein structures and primate genomics.

Key Info

• URL: https://github.com/Illumina/PrimateAI-3D
• Category: VEP
• API: Yes
• Free: Free (Academic)
• ACMG Relevance: PP3, PM1

Why It Matters

Provides critical interpretability for non-loss-of-function variants by mapping biomolecular complex interactions in vivo.

How to Use

See https://github.com/Illumina/PrimateAI-3D for documentation and access.

STRC Research Usage

Documented. Requires local installation or specialized access for STRC E1659A testing.

Next Steps

• Test with STRC E1659A variant
• Verify API access
• Document specific results

Connections

• STRC Variant c.4976A>C — Misha [see-also]
• STRC Gene [about]