Pangolin

Predicts splice site strength and aberrant usage across multiple mammalian tissues.

Key Info

• URL: https://github.com/bw2/Pangolin
• Category: Splicing
• API: Yes
• Free: Free
• ACMG Relevance: PP3

Why It Matters

Trained on tissue-specific splicing quantifications from multiple species, outperforming older models on non-missense variants.

How to Use

See https://github.com/bw2/Pangolin for documentation and access.

STRC Research Usage

PARTIAL — pip install failed, GitHub clone timed out. Tissue-specific splicing predictor — would be better than SpliceAI for E1659A inner ear context.

Next Steps

• Test with STRC E1659A variant
• Verify API access
• Document specific results

Connections

• STRC Variant c.4976A>C — Misha [see-also]
• STRC Gene [about]