MetaRNN

Prioritizes rare non-synonymous SNVs via recurrent neural networks.

Key Info

• URL: https://vep.varianteffect.org/ SITE DOWN (ECONNREFUSED as of 2026-04-09)
• Alt URL: Scores available in dbNSFP; also see https://github.com/Chang-Li2019/MetaRNN
• Category: VEP
• API: Via dbNSFP pre-computed scores
• Free: Free
• ACMG Relevance: PP3
• Link Status: SITE DOWN 2026-04-09

Why It Matters

Outperforms traditional linear meta-predictors by accurately modeling the non-linear relationships between independent constituent scores.

How to Use

See https://vep.varianteffect.org/ for documentation and access.

STRC Research Usage

Documented. Requires local installation or specialized access for STRC E1659A testing.

Next Steps

• Test with STRC E1659A variant
• Verify API access
• Document specific results

Connections

• STRC Variant c.4976A>C — Misha [see-also]
• STRC Gene [about]