MaxEntScan

Evaluates 5’ and 3’ splice site strength employing the Maximum Entropy Principle.

Key Info

• URL: https://github.com/gagneurlab/splicemodels BROKEN — repo does not exist
• Alt URL: https://github.com/kepbod/maxentpy (Python implementation ★18) or http://hollywood.mit.edu/burgelab/maxent/Xmaxentscan_scoreseq.html (original Perl)
• Category: Splicing
• API: Yes (via Python package maxentpy)
• Free: Free
• ACMG Relevance: PP3
• Link Status: BROKEN 2026-04-09 — original link wrong. Best Python port: kepbod/maxentpy

Why It Matters

Remains a highly established, transparent baseline metric for calculating the relative creation or destruction of consensus splice motifs.

How to Use

Install Python implementation: pip install maxentpy. Original Perl scripts at MIT Burge Lab. See https://github.com/kepbod/maxentpy for docs.

STRC Research Usage

Not directly applicable to E1659A via API. Requires local installation or web interface. See documentation for manual usage.

Next Steps

• Test with STRC E1659A variant
• Verify API access
• Document specific results

Connections

• STRC Variant c.4976A>C — Misha [see-also]
• STRC Gene [about]