Manta

Rapid structural variant caller tailored specifically for high-throughput clinical sequencing pipelines.

Key Info

• URL: https://github.com/Illumina/manta
• Category: CNV Analysis
• API: Yes
• Free: Free
• ACMG Relevance: N/A
• Link Status: ARCHIVED 2026-04-09 — repo archived by Illumina (★462, last push Oct 2025). Still functional, widely used in pipelines.

Why It Matters

Exceptional at discovering break-end structural variants and medium-sized indels that read-depth alone cannot accurately resolve.

How to Use

See https://github.com/Illumina/manta for documentation and access.

STRC Research Usage

Not directly applicable to E1659A via API. Requires local installation or web interface. See documentation for manual usage.

Next Steps

• Test with STRC E1659A variant
• Verify API access
• Document specific results

Connections

• STRC Variant c.4976A>C — Misha [see-also]
• STRC Gene [about]