MPC

Calculates missense badness, PolyPhen-2, and constraint metrics for variant scoring.

Key Info

• URL: https://broadinstitute.org/
• Category: VEP
• API: Limited
• Free: Free
• ACMG Relevance: PP3
• Link Status: Unchecked

Why It Matters

Highly effective for identifying pathogenic missense variants within regions of proteins that are highly intolerant to variation.

STRC Research Usage

Not yet tested on E1659A.

Next Steps

• Verify URL accessibility
• Test with STRC E1659A variant if applicable
• Document specific results

Connections

• STRC Variant c.4976A>C — Misha [see-also]
• STRC Gene [about]