FoldX

Calculates empirical energy terms for evaluating wild-type and mutant protein stability.

Key Info

• URL: http://foldxsuite.crg.eu/
• Category: Protein Structure
• API: Limited
• Free: Free (Academic)
• ACMG Relevance: PP3

Why It Matters

Outputs 20 distinct energy terms utilized specifically to analyze hydrogen bonding, Van der Waals forces, and electrostatic clashes.

How to Use

See http://foldxsuite.crg.eu/ for documentation and access.

STRC Research Usage

PARTIAL — Not available via pip. Requires academic license download from foldxsuite.crg.eu. Industry standard for empirical ΔΔG calculation.

Next Steps

• Test with STRC E1659A variant
• Verify API access
• Document specific results

Connections

• STRC Variant c.4976A>C — Misha [see-also]
• STRC Gene [about]