Eigen — Eigen-PC

Uses unsupervised spectral approaches to aggregate functional annotations into a single score.

Key Info

• URL: http://www.columbia.edu/~ii2135/eigen.html
• Category: VEP
• API: Yes
• Free: Free
• ACMG Relevance: PP3

Why It Matters

Avoids the biases of labeled training datasets, relying entirely on the underlying structure of functional epigenetic markers.

How to Use

See http://www.columbia.edu/~ii2135/eigen.html for documentation and access.

STRC Research Usage

Documented. Requires local installation or specialized access for STRC E1659A testing.

Next Steps

• Test with STRC E1659A variant
• Verify API access
• Document specific results

Connections

• STRC Variant c.4976A>C — Misha [see-also]
• STRC Gene [about]