EVE (Evolutionary model of Variant Effect)

Maps viral and human fitness landscapes via deep generative models.

Key Info

• URL: https://evemodel.org/
• Category: VEP
• API: Yes
• Free: Free
• ACMG Relevance: PP3, BP4

Why It Matters

Ranks variants on a continuous pathogenicity spectrum based purely on evolutionary sequence constraints without supervised labels.

How to Use

See https://evemodel.org/ for documentation and access.

STRC Research Usage

PARTIAL — API returns 404 for STRC (Q7RTU9). STRC may not be in pre-computed EVE database. Would provide zero-shot pathogenicity score free of clinical data bias.

Next Steps

• Test with STRC E1659A variant
• Verify API access
• Document specific results

Connections

• STRC Variant c.4976A>C — Misha [see-also]
• STRC Gene [about]