EVE (Evolutionary model of Variant Effect)

Maps viral and human fitness landscapes via deep generative models.

What it does

Ranks variants on a continuous pathogenicity spectrum based purely on evolutionary sequence constraints without supervised labels.

How to use

See https://evemodel.org/ for documentation and access.

STRC usage

PARTIAL — API returns 404 for STRC (Q7RTU9). STRC may not be in pre-computed EVE database. Would provide zero-shot pathogenicity score free of clinical data bias.

Connections

• STRC Variant c.4976A>C — Misha [see-also]
• STRC Gene [about]
• [part-of] Tools index