DeepSEA

Deep learning-based sequence model for predicting the chromatin effects of sequence alterations.

Key Info

• URL: https://hb.flatironinstitute.org/
• Category: Regulatory
• API: Yes
• Free: Free
• ACMG Relevance: PP3

Why It Matters

Directly predicts how a single nucleotide change will alter localized chromatin accessibility and transcription factor binding.

How to Use

See https://hb.flatironinstitute.org/ for documentation and access.

STRC Research Usage

Not directly applicable to E1659A via API. Requires local installation or web interface. See documentation for manual usage.

Next Steps

• Test with STRC E1659A variant
• Verify API access
• Document specific results

Connections

• STRC Variant c.4976A>C — Misha [see-also]
• STRC Gene [about]