DDGun — DDGun3D

Untrained algorithm predicting the folding stability impact of amino acid substitutions.

What it does

Entirely circumvents the overfitting pitfalls of supervised machine learning by relying exclusively on biophysical principles.

How to use

See https://github.com/biofold/ddgun for documentation and access.

STRC usage

PARTIAL — pip install succeeds but BioPython compatibility issues. Requires hhblits for full functionality. Untrained stability predictor would give unbiased ΔΔG.

Connections

• STRC Variant c.4976A>C — Misha [see-also]
• STRC Gene [about]
• [part-of] Tools index