DANN

Uses deep neural networks to score the deleteriousness of genetic variants.

What it does

Provides a non-linear counterpart to CADD, often yielding better separation between pathogenic and benign alleles.

How to use

DANN scores available as pre-computed whole-genome annotations. Access via dbNSFP or download from https://cbcl.ics.uci.edu/public_data/DANN/. Already tested on STRC E1659A: score 0.9946 (highly deleterious).

STRC usage

Documented. Requires local installation or specialized access for STRC E1659A testing.

Connections

• STRC Variant c.4976A>C — Misha [see-also]
• STRC Gene [about]
• [part-of] Tools index