ConSurf

Estimates the evolutionary conservation of amino and nucleic acid positions using precise phylogeny.

Key Info

• URL: http://consurf.tau.ac.il/
• Category: Conservation
• API: Yes
• Free: Free
• ACMG Relevance: PP3

Why It Matters

Applies accurate empirical Bayesian and maximum likelihood methods to identify slowly evolving, structurally critical protein positions.

How to Use

See http://consurf.tau.ac.il/ for documentation and access.

STRC Research Usage

PARTIAL — API timed out. Requires manual web submission of Q7RTU9. Would project conservation scores onto 3D structure — complementary to our flat alignment.

Next Steps

• Test with STRC E1659A variant
• Verify API access
• Document specific results

Connections

• STRC Variant c.4976A>C — Misha [see-also]
• STRC Gene [about]