BRAVO — TOPMed

Variant browser providing allele frequencies for over 868 million variants from whole genomes.

Key Info

• URL: https://bravo.sph.umich.edu/
• Category: Population
• API: Yes
• Free: Free
• ACMG Relevance: BA1, BS1, PM2

Why It Matters

Features deeply sequenced (>38X) WGS data, capturing ultra-rare variation that is routinely missed by standard exome cohorts.

How to Use

See https://bravo.sph.umich.edu/ for documentation and access.

STRC Research Usage

VERIFIED — E1659A NOT FOUND (404). Confirms variant rarity — absent from 868M variants in TOPMed deep WGS. Supports PM2.

Next Steps

• Test with STRC E1659A variant
• Verify API access
• Document specific results

Connections

• STRC Variant c.4976A>C — Misha [see-also]
• STRC Gene [about]