Sources
Ingestion layer: each source represents an external document (DR output, PDF, paper, review, correspondence, practical guide). Atomic concept notes derived from sources live in notes; paper notes live in papers.
Canonical program documents
- STRC-PROBLEM — problem statement; read first by every routine working in the vault
- Deep Research - STRC Hearing Loss Treatment — family-facing comprehensive guide (Claude DR, 634 sources)
Clinical / practical guides
- 2026-02-07-strc-diagnosis-vus-guide (EN) · 2026-02-07-strc-diagnosis-vus-guide-RU (RU) — variant interpretation playbook
- 2026-02-07-strc-hearing-loss-treatment (EN) · 2026-02-07-strc-hearing-loss-treatment-RU (RU) — treatment landscape summary
- 2026-02-07-strc-practical-guide-hk — HK-specific diagnostic/treatment steps for Misha’s case
- Legal Structure for Cross-Border Rare Disease Foundation — MISHA Foundation legal scaffold
- Patient Registry Blueprint for STRC Hearing Loss — registry design doc
Primary-literature sources
- 2019-12-li-4pba-cdh23-neuroreport — 4PBA rescue of CDH23 in OHC (precedent for h01 Phase 4g repurposing branch)
- 2021-12-holt-strc-dual-aav-science-advances — Holt lab dual-AAV STRC (direct h03 precedent)
- 2024-genereviews-strc-dfnb16 — canonical GeneReviews entry
- 2025-db-oto-chord-trial-nejm — DB-OTO OTOF trial NEJM (dual-AAV clinical validation)
- 2026-01-iranfar-dual-aav-strc-ctm — Iranfar dual-AAV STRC CTM (second independent h03 validation)
- 2026-04-07-chen-liheng-strc-reply — Chen Liheng Shu-lab correspondence re: collaboration
- 2026-04-17-sun-rbm24-strc-splicing — Sun 2026 RBM24 STRC splicing (h06 mRNA-therapy source)
- Duan_2018_micro_dystrophin_AAV — Duan micro-dystrophin AAV (engineering precedent for mini-STRC)
- Mendell_2020_micro_dystrophin_clinical — Mendell micro-dystrophin clinical trial (mini-STRC direct precedent for h03)
- Omichi_2020_AAV_hair_cell_transduction — Omichi hair-cell AAV transduction
- Gadenstaetter_2024_inner_ear_gene_therapy_review — inner-ear gene therapy review
- Verpy_2008_Stereocilin_Nature — Verpy canonical stereocilin Nature paper (foundational)
Correspondence
- 2026-04-07-chen-liheng-strc-reply — reply on STRC collaboration (listed above under primary literature for graph cohesion)
Connections
[part-of]Hypotheses — Live Ranking[see-also]notes · papers · Literature audit hub