What they found
Comprehensive review of MET channel biology: biophysics, gating, Ca²⁺ permeation, adaptation, molecular identity (TMC1/TMC2), and tonotopy. Synthesizes data on channel numbers per stereocilium (~2), bundle conductance (~1–6 nA peak), single-channel conductance gradients (apical ~100 pS to basal ~300 pS in mouse), and the role of Ca²⁺ in fast and slow adaptation.
Numbers that matter
- MET channels per stereocilium: ~1–2 (i.e., ~50–100 per OHC for a bundle of 50–70 stereocilia)
- n_channels = 134 in the h05 RBM24 model cites “Fettiplace 2017” — the correct citation is Fettiplace & Kim 2014 (this paper). The year “2017” is wrong. 134 channels is plausible for a mid-frequency OHC (67 stereocilia × 2 channels each).
- Ca²⁺ permeation fraction f_Ca: ~15% at physiological ionic conditions (consistent with Beurg 2006)
- Single-channel conductance: 145–210 pS apical-to-basal in rat (matches Beurg 2006)
Fit to h05
This review is the correct source for n_channels = 134 (replacing the phantom “Fettiplace 2017”). The value itself is plausible per the review’s channel density data. Note: the review itself notes variability in channel number across cochlear position and species; 134 should be treated as an order-of-magnitude estimate, not a precise measurement.
Connections
- STRC Calcium Oscillation Acoustic Therapy — MET channel count (n_channels)
[see-also]2006-beurg-met-channel-conductance — g_MET value[part-of]calcium-oscillation (literature-params topic)