log

h05 log

2026-04-23

• Misha-specific PD: realistic affinity penalty 10-100× outside feasibility window; acoustic therapy = free adjunct → STRC Ca Oscillation Maternal-Only PD
• No tier change; stays A. Next: SPR/BLI E1659A affinity penalty measurement.
• Parameter provenance audit complete + post-audit fix applied: 4 phantom cites removed (Wu 2011, Sharma 2018, Cha 2010, Krey 2015), Chao 2010→Chao 2011 (PMID 21458670), PKA K_cAMP cite corrected to Surdo 2017 (PMID 29074866). CREB-P dephos 2-4× faster than lit flagged, STRC mRNA/protein t½ cross-script mismatches (4× and 20×) flagged explicitly. Phase 3 topological verdict defensible. Tier A held. → STRC h05 Parameter Provenance Audit 2026-04-23

2026-04-21

• Phase 3 globally stable; max Re(λ) = −5×10⁻⁶/s; true Hill n=4.33 confirmed → STRC Calcium Oscillation Acoustic Therapy
• Phase 2 robustness index 0.91; Phase 1 RBM24 ODE baseline established → STRC Calcium Oscillation Acoustic Therapy
• Initial assignment: A-tier, Mech 3, Deliv 4, Misha 2 → STRC Hypothesis Ranking

2026-04-23

• #5 Ca oscillation: stays A. Maternal-allele-only PD: rescue only if penalty ≤3× at fold ≥1.3. Most plausible 10-100×. → STRC Ca Oscillation Maternal-Only PD
• #5 Ca Oscillation post-audit fix: A held. 4 phantoms removed (Wu 2011, Sharma 2018, Cha 2010, Krey 2015). PKA K_cAMP cite Zaccolo 2007→Surdo 2017 (PMID 29074866); Chao 2010→Chao 2011 (PMID 21458670). CREB dephos 2-4× faster than lit flagged. STRC mRNA/protein t½ cross-script 4× and 20× inconsistencies flagged. Phase 3 topological verdict robust. → STRC h05 Parameter Provenance Audit 2026-04-23

Connections

• [part-of] h05 hub